Online Diagnosis and Prescription

In the past several years, researchers have developed drugs specifically designed to target key proteins of HCV. Current Hepatitis C treatments are made up of combinations of drugs called direct-acting antivirals (DAAs). DAAs directly target the Hep C virus in different ways to stop it from making copies of itself and do this so well that they promise a much brighter future for people living with Hepatitis C. DAAs deliver treatments with shorter treatment times, much higher cure rates, and fewer side effects.

Direct-acting antivirals (DAAs) are the standard of care for chronic HCV infection today. These drugs work by attacking HCV directly. This means they’re more targeted than older treatments such as Interferons. Also, they don’t affect as many systems in your body as Interferons, so they may not cause as many side effects. All DAAs are oral drugs.

 

Side effects of DAAs may include: anemia, diarrhea, fatigue, headaches, nausea, vomiting and slow heartbeat.

 

Protease inhibitors (NS5A inhibitors):

The action of these drugs isn’t fully understood. They may work by stopping the virus from copying itself. They may also help prevent drug resistance (when a drug no longer works to treat a condition).

These drugs are used to treat all HCV genotypes. They’re used alone or in combination with other medications.

 

Examples of directed inhibitors include:

  • ombitasvir (a component of the combination drug Viekira Pak)

  • elbasvir (a component of the combination drug Zepatier)

  • daclatasvir (Daklinza)

  • ledipasvir (a component of the combination drug Harvoni)

 

Nucleotide/nucleoside and nonnucleoside polymerase inhibitors (NS5B inhibitors):

These drugs work by blocking a protein called NS5B. The Hepatitis C virus needs this protein to replicate itself and survive. Examples of these drugs include:

  • sofosbuvir (Sovaldi)

  • dasabuvir

 

Combination drugs:

All DAAs are given as combinations. Some combinations are made into single pills to make taking the medication easier. Brand names of current combination therapies include:

  • Harvoni

  • Viekira Pak

  • Zepatier

  • Technivie

  • Epclusa

  • Vosevi

  • Mavyret

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